Administration of rhAPC reduces endotoxin-induced leukocyte accumulation to the airspaces. Leukocytes present in BALF recovered 16 hours after endobronchial LPS-instillation from volunteers who received rhAPC (•) or placebo (○). Solid bar represents the mean of log values for each group; n = 8 for rhAPC and n = 7 for placebo. (A) Total WBCs recovered per mL of lavage fluid. Administration of rhAPC significantly reduced recovery of all leukocytes, P = .037 by Student t test. (B) Total neutrophils recovered per mL of lavage fluid. Administration of rhAPC reduced recovery of neutrophils, P = .048 by Student t test.