Figure 6.
Inhibition of cGMP transport into platelet membranes. Membrane vesicles were incubated with [3H]cGMP (2 μM) for 10 minutes at 37°C in the presence of dipyridamole (▪), indomethacin (♦), or MK571 (▴) at the concentrations indicated. Rates of ATP-dependent [3H]cGMP transport were determined as described in “Patients, materials, and methods” and calculated as percent inhibition of control [3H]cGMP transport in the presence of the identical concentrations of the solvent used. Data represent mean values ± SD from 3 determinations.