Combination of cytarabine and SU11248 on apoptosis. MV4-11 cells cultured in the presence of SU11248, cytarabine, or both were analyzed for PARP cleavage by Western blot after 24 hours of exposure to agents. Representative results from 1 of 3 experiments are displayed. Increasing doses of either single agent increased the amount of cleaved PARP detected. The combination of agents produced a dramatic increase in the cleavage product with almost no full-length PARP detected.