Schematic representation of Dectin-1-mediated signaling in macrophages. Dectin-1 ITAM-like motif becomes phosphorylated on ligand binding and is likely to recruit a novel SH2-containing kinase that mediates many of the downstream signaling pathways. The signaling mediators examined in this report are shown in blue and putative novel mediators are shown in red. Red lines indicate proposed signaling pathways mediated by these intermediates and black lines indicate previously suggested (dotted lines) or established (solid lines) interactions.^{1,11,12,26,42}