Figure 5.
Effects of dexamethasone in combination with patupilone on MM cell proliferation and survival. MM.1S cells were incubated in the presence of dexamethasone (0, 0.01, 0.1, and 1 μM) and patupilone (0, 0.01, 0.1, 1, and 10 nM) for 48 hours. Proliferation was measured by 3H-[dT] uptake (A), and survival was measured by MTS assay (B) relative to untreated control cells. Patupilone appeared to be responsible for most of the response at high patupilone concentration. Error bars indicate ± standard deviation of triplicate experiments.