Figure 6.
![Figure 6. IL-6 and IGF-1 do not protect against patupilone. IL-6 and IGF-1 are growth and survival factors for MM cells. Both inhibit dexamethasone-induced apoptosis. MM.1S cells were incubated for 24 hours in the absence (⋄) or presence of IL-6 (100 ng/mL, ▵), IGF-1 (200 ng/mL, □), or patupilone 0, 0.1, 1, or 10 nM. Proliferation was measured by 3H-[dT] uptake (A), and survival was measured by MTS assay (B). Both assays were measured relative to internal controls without patupilone, in the absence or presence of IL-6 or IGF-1. Error bars indicate ± standard deviation of triplicate experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/105/1/10.1182_blood-2004-06-2499/6/zh80010571480006.jpeg?Expires=1735594307&Signature=uLw~J~yEjzSMFhljzxtzhimv8eQCj27yjtd7QZFke9X2fS4-JncMSm21kzAvyre6fT5TIUCKqDmIJNSzn6REzCK~ONSL9eYGesUJB6ApGwUrn9opqvG3PahZ3JNAS1TNffEUiI9~5~eUSmO-R-UmSD4jM3LMHvOtaHpTFCJ7d-qNn2YgfYi7g6Rb4vIJ3vfPHWY1G43YOu01Ztx7HPISwLlvSyaz~StYS8S7nHJu42tAypn3mSMw23m6dI-9uo7KguQw44JIV5rJ2QwFfvBmz970AAgOugRfv3pGIC3HjqZWQysBl5PDEOMktiq6GggcKJ2d97wN29ycd4fp2iawPA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
IL-6 and IGF-1 do not protect against patupilone. IL-6 and IGF-1 are growth and survival factors for MM cells. Both inhibit dexamethasone-induced apoptosis. MM.1S cells were incubated for 24 hours in the absence (⋄) or presence of IL-6 (100 ng/mL, ▵), IGF-1 (200 ng/mL, □), or patupilone 0, 0.1, 1, or 10 nM. Proliferation was measured by 3H-[dT] uptake (A), and survival was measured by MTS assay (B). Both assays were measured relative to internal controls without patupilone, in the absence or presence of IL-6 or IGF-1. Error bars indicate ± standard deviation of triplicate experiments.
