Patupilone inhibits proliferation of MM cells adherent to BMSCs. MM patient BMSCs were cultured with or without MM.1S cells in the presence of 0, 1, or 10 nM patupilone. Subsequent proliferation at 48 hours was measured by ³H-[dT] uptake (A). Supernatants from the coculture of BMSCs with MM cells were analyzed by ELISA for VEGF (B) and IL-6 (C), 2 important factors for MM cell migration and proliferation.