Patupilone extends survival and inhibits tumor growth in an MM xenograft mouse model. RPMI 8226 cells were injected into the flanks of 24 beige-xid nude mice. Six days after tumor cell injection, mice were randomly separated into 1 of 3 treatment groups: control vehicle only (long dashed line), 1 dose of patupilone at 4 mg/kg intravenously (long and short dashed line), or 4 weekly doses of patupilone at 2.5 mg/kg intravenously (short dashed line). Tumor measurements were performed twice weekly, and tumor volumes were calculated. When tumors reached 2 cm in the longest diameter, mice were killed. (A) Kaplan-Meier survival curves of the mice in each group were plotted relative to the number of days after tumor injection. (B) Mean tumor volumes for mice in each group were calculated until day 16, the day when the first mice were killed. Control (♦), patupilone at 4 mg/kg intravenously (▴), or 4 weekly doses of patupilone at 2.5 mg/kg intravenously (▪). (C) Mice were weighed once per week, and average weight was calculated.