Pharmacokinetics of porcine skin dermatan sulfate in HCII^+/+ mice. Mice were injected intravenously with 320 000 dpm ³⁵H-labeled dermatan sulfate at time = 0 minute and were killed at the times indicated. Total radioactivity present in plasma and urine was determined. The mice were then perfused with 50 mL PBS, and total radioactivity present in the kidneys, heart, lungs, and liver was determined. In a separate experiment, plasma was collected from mice simultaneously injected with ³⁵H-labeled dermatan sulfate and rose bengal. The data represent the mean ± SD of 3 animals studied at each time point (overlapping error bars are offset horizontally). (A) Plasma (○); urine (•); kidneys (□); and plasma (^*) from mice injected with rose bengal. (B) Heart (▪), lungs (▵), and liver (▴). The dashed line in panel A indicates the sum of the mean radioactivity recovered at each time point.