Antithrombotic effects of glycosaminoglycans. Porcine skin, S plicata and A nigra dermatan sulfate, and chondroitin 4-sulfate (C4S) were administered intravenously at a dose of 10 mg/kg to HCII^+/+ (□) or HCII^-/- (▦) mice. Porcine intestinal heparin was administered at a dose of 0.125 mg/kg. The glycosaminoglycan or an equal volume of 0.15 M NaCl (control) was given 15 minutes prior to rose bengal. The number within each column indicates the number of mice studied. ^*P < .0001 versus HCII^+/+ control; ^**P > .2 versus HCII^+/+ control; †P ≥ .08 versus HCII^-/- control; ‡P < .02 versus HCII^-/- control; and §P = .4 versus HCII^+/+ heparin.