Minimal toxicity of CCI-779 in NOD/SCID mice. Mice (4 per group) were injected intraperitoneally with vehicle alone or with varying doses of CCI-779 daily for 10 days, as described in “Materials and methods.” (A) Weight shown in grams (mean ± SD; n = 4). Solid bars on x-axis denote days of treatment. (B) Platelet and WBC counts enumerated at day 6 (upper panel) and day 12 (lower panel) of treatment and shown as percentage of control (vehicle alone) (mean±SD; n = 4). Asterisks denote values significantly different (P < .05) from control.