Effects of K-11706 or K-13144 on reticulocyte counts and numbers of CFU-Es. (A) Effects of K-11706 or K-13144 on the inhibition of reticulocyte counts induced by IL-1β or TNF-α in ICR mice. Experimental conditions were the same as those described in the legend to Figure 4A (n = 5-12). ^* indicates significance compared with control, P < .005; ^**, significance compared with IL-1β, P < .005; ^***, significance compared with TNF-α, P < .005. (B) Effects of K-11706 on the inhibition of the numbers of CFU-Es from the bone marrow of ICR mice induced by IL-1β or TNF-α. Experimental conditions were the same as those described in the legend to Figure 4A. Mice were killed on day 4 (n = 6-8). ^* indicates significance compared with control, P < .005; ^**, significance compared with control, P < .01; ^***, significance compared with IL-1β, P < .005; ^****, significance compared with TNF-α, P < .025; ^*****, significance compared with control, P < .05.