Neutrophilia and survival of SCLtTA/BCR-ABL mice after induction of BCR-ABL. (A) The graph shows the percentages of neutrophils (shown as mean ± SE) among total white blood cells in SCLtTA/BCR-ABL double-transgenic mice (▪) or controls (□). Controls consisted of wild-type (n = 3) and BCR-ABL single-transgenic (n = 6) mice, which had similar values. The percentage of neutrophils was greater in SCLtTA/BCR-ABL mice than in controls (P < .05) for each time point up to day 45 (on day 54, the ranges were 20%-79% for SCLtTA/BCR-ABL and 5%-12% for control animals, and on day 62 the ranges were 47%-85% and 11%-14%, respectively). SE for the control mice was at each point less than 2.1 and, therefore does not show on the diagram. (B) Kaplan-Meier-style survival and morbidity curve of induced double-transgenic mice, depicting overall survival and disease phenotype (▪, myeloid; □, sequential myeloid and lymphoblastic) after induction of BCR-ABL by tetracycline removal.