Platelet aggregation to collagen and convulxin following immune-mediated cleavage is restored by MMP inhibitor pretreatment. Washed platelets (3 × 10⁸/mL) were aggregated using collagen (10 μg/mL), convulxin (10 ng/mL), or TRAP (10 μM) alone (A), following preincubation with the combination of monoclonal IV.3 (25 μg/mL) and 9012.2 (25 μg/mL) (B-C), following 10 minutes preincubation with GM6001 (300 μM), followed by 45 minutes' incubation with antibodies. Results shown are representative of 3 independent experiments.