Phylogenetic trees from early/late E2/NS1 HVR1 clonal sets from ESLD progressors (cases) and nonprogressors (controls), constructed in MEGA2.1 using the neighbor-joining method of Saitou and Nei.23 Sequences from early time point clones are labeled with an “E” at the end of the sequence name. Late time point sequences are labeled with an “L.” One matched pair is not represented here due to a subtype shift in the progressor that precluded tree generation in MEGA. Progressors trended toward greater genetic diversity at the early time point than nonprogressors (P = .04) and demonstrated significant narrowing of genetic diversity over time, regardless of infection status (P = .04). Nonprogressors maintained the same level of diversity over the study duration.
