Amino acid sites from the HVR1 with statistically significant variability in hydropathic character. Hydrophobicity was determined using the scale of Black and Mould.²⁵  Hydrophobic residues include F, I, W, Y, L, V, M, P, C, and A. Neutral residues include G, S, and T. Hydrophilic residues include K, Q, N, H, E, D, and R. Proportion of residue hydropathic characteristics are presented as decreasing hydrophobicity from 0% up: hydrophobic residue proportions are represented in black, neutral in dark gray, and hydrophilic in light gray.