Gene induction by 1018 ISS in a representative patient. Gene/ubiquitin ratios for 6 interferon-inducible genes in PBMCs from patient 113, treated with the highest dose of 1018 ISS (0.5 mg/kg). Values for the more highly expressed genes were multiplied as indicated. Samples were taken before and 24 hours after 1018 ISS injection. Visit 4 included the second and visit 6 included the last of the 4 injections of 1018 ISS.