Observed median clofarabine concentrations versus time overlaid with model predicted concentrations for each dose group. Predicted concentrations were based on the average of the pharmacokinetic parameters pooled across all patients. One outlier in the 30 mg/m² dose group at the end-of-infusion after the dose on day 4 (1134 ng/mL) is not shown. Clofarabine concentrations, (•); model predicted concentrations, solid line.