Figure 3.
The primary mechanism of the cytotoxic effects of CEP-701 on primary ALL cells is the induction of apoptosis. (A) Dose-response curves showing the mean MTT and annexin-V binding (AVB) apoptosis assays for all CEP-701–sensitive samples (n = 18). Error bars indicate standard error of the mean (SEM). (B) Correlation of MTT and AVB results at the CEP-701 50-nM dose level. r2 indicates Pearson correlation coefficient; the solid line, best-fit line by linear regression; and the dotted lines, 95% confidence interval of best-fit line.
