Figure 4.
Figure 4. Mutations of cloned VκA27 sequences from 2 CVID patients (high and low mutated) and from 2 adult controls. Mutations in VκA27 are represented by 11 sequences randomly selected from each patient and control. Hot spot indicates the two Fnu4HI restriction sites in the CDR1. The columns illustrate the number of mutations in each codon; above the axis, preventing cleavage in the hot spot; below the axis, not affecting cleavage.

Mutations of cloned VκA27 sequences from 2 CVID patients (high and low mutated) and from 2 adult controls. Mutations in VκA27 are represented by 11 sequences randomly selected from each patient and control. Hot spot indicates the two Fnu4HI restriction sites in the CDR1. The columns illustrate the number of mutations in each codon; above the axis, preventing cleavage in the hot spot; below the axis, not affecting cleavage.

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