Breadth and magnitude of HCV-specific immunity by group reveal no differences by HIV-1 serostatus. Comparison of monoinfected (HCV Ab positive, HIV-1 Ab negative, group AB) and coinfected (HCV Ab positive, HIV-1 Ab positive, group CD) subjects reveals no significant difference in number of HCV epitopic regions targeted (A) nor the intensity of the response (B). The breadth (C) and magnitude (D) of HCV-specific CD8⁺ T-cell responses are shown for the same subjects further subdivided by HCV RNA status (group A: monoinfected, HCV viremic; group B: monoinfected, HCV controller; group C: HIV-1 coinfected, HCV viremic; group D: HIV-1 coinfected, HCV controller), demonstrating higher breadth and magnitude in group B compared with group A.