Figure 11.
Effect of plasminogen on proteolysis of globin and fibrinogen by scuPA/suPAR. scuPA/suPAR (25 nM) was incubated with C14-globin (A) or 125I-fibrinogen (B) in the presence of increasing concentrations of Glu-plasminogen at 37°C for 3 hours. Radioactivity in the TCA-soluble supernatants that contained cleavage products of 14C-globin or 125I-fibrinogen was measured.