Figure 4.
Figure 4. HOXB6 primary transplant chimeras have mild splenomegaly and impaired erythropoiesis and thrombopoiesis. (A) HOXB6 and HOXB6WG transplant chimeras were anemic compared with MIG controls and HOXB6WG mice had a greater degree of anemia than HOXB6 mice. Results shown are means ± SD. n = 17 for HOXB6, 16 for HOXB6WG, 14 for HOXB6NA, and 13 for MIG cohorts. (B) HOXB6, HOXB6WG, and HOXB6NA primary transplant chimeras all had moderate thrombocytopenia compared with MIG controls. P less than .005 for all vectors. n for each cohort as in panel A. Results shown are means ± SEM. (C) CFC assays performed with spleen suspensions from primary transplant chimeras demonstrate significantly reduced BFU-E frequency in mice that received transplants of HOXB6- and HOXB6WG-overexpressing bone marrow. Results represent means ± SEM from 4 individual experiments for MIG, 3 for HOXB6, and 2 each for HOXB6WG and HOXB6NA.

HOXB6 primary transplant chimeras have mild splenomegaly and impaired erythropoiesis and thrombopoiesis. (A) HOXB6 and HOXB6WG transplant chimeras were anemic compared with MIG controls and HOXB6WG mice had a greater degree of anemia than HOXB6 mice. Results shown are means ± SD. n = 17 for HOXB6, 16 for HOXB6WG, 14 for HOXB6NA, and 13 for MIG cohorts. (B) HOXB6, HOXB6WG, and HOXB6NA primary transplant chimeras all had moderate thrombocytopenia compared with MIG controls. P less than .005 for all vectors. n for each cohort as in panel A.. Results shown are means ± SEM. (C) CFC assays performed with spleen suspensions from primary transplant chimeras demonstrate significantly reduced BFU-E frequency in mice that received transplants of HOXB6- and HOXB6WG-overexpressing bone marrow. Results represent means ± SEM from 4 individual experiments for MIG, 3 for HOXB6, and 2 each for HOXB6WG and HOXB6NA.

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