Summary of etoposide-induced breakpoints within the MLL bcr. Localization of repetitive elements in 8.3-kb MLL bcr, and distribution of breakpoints associated with translocations and insertions (above the line) or intragenic duplications (below the line). Alu elements in same orientation (light gray arrows; 799-1109, 1119-1420, 1423-1716, 1927-2215, 3973-4268, 4765-5094, 6072-6372, 7163-7427), LINE elements (black arrows; 3490-3589, 3691-3972, 4269-4612, 5610-5998), low copy MER repeat (dark gray arrows; 6959-7162, 7428-7558). ^*Sequence homology to a putative topo II recognition sequence (according to Gu et al²² ).