Multilineage engraftment of NOD/SCID mice. (A) Analysis of myelopoiesis, B lymphopoiesis, and megakaryocytopoiesis in the BM of the NOD/SCID mice that received transplants of either normal G-CSF-mobilized PB (□;n = 3) or IM PB (▪;n = 3) CD34⁺ cells. Overall distribution of myeloid (CD33⁺) lineages, B-lymphoid (CD19⁺) lineages, progenitor cells (CD34⁺), and megakaryocytes (CD41⁺) among human cells (CD45⁺). Values are shown as the mean ± SD. (B) Representative flow cytometric analysis of BM from mice that received transplants of PB CD34⁺ cells from a G-CSF-mobilized volunteer (top row) or a patient with IM (bottom row). BM cells were analyzed by flow cytometry at 9 to 15 weeks after transplantation.