Figure 5.
Summary of proliferative responses to RhD autoantigen peptides by PBMCs from Patients with CLL with AIHA. ▪ indicates proportion of D-positive Patients with CLL with secondary AIHA (n = 8) whose PBMCs proliferate in response to peptides spanning the RhD protein. □ indicates results of parallel studies17 to map RhD peptides that stimulate PBMCs from patients with patients with primary AIHA patients (n = 11). The peptide panel is reduced to the 42 sequences with less overlap used in the previous work17 and is numbered accordingly. There is a significant correlation (Rs = 0.55; P < .0001) between the abilities of each RhD peptide to elicit proliferative responses in patients with primary and secondary AIHA.