Validation of DLBCL consensus clusters in an independent dataset. Application of consensus clustering and meta-consensus (as in Figure 1B) to the independent DLBCL series (top right panel). One of the identified consensus clusters was highly enriched for HR transcripts (P < 2.2 × 10^–16, top left panel). Application of consensus clustering and meta-consensus to the non-HR cluster (bottom right panel). The non-HR tumors sorted into 2 discrete clusters with highly significant enrichment for either BCR/proliferation or OxPhos transcripts (P = < .0009, bottom left panel).