Induction of apoptosis 2-deoxyglucose. MO7e cells transformed by BCR-ABL were treated with glucose (4.5 mg/mL), 3-OMG (4.5mg/mL), and 2-DOG (4.5 mg/mL) or left untreated (control) as indicated (A-B). Annexin V-positive cell staining, induction of caspase-3 activity (n = 3) (A), and cell-cycle distribution indicated by shaded areas (B) were determined in a 72-hour culture. Error bars indicate standard error of the mean. ^*Significant differences (P < .05) were observed between treated and control cells (n = 3).