Figure 6.
uPAR84-95 inhibits SDF-1–dependent migration of CD34+ KG1 and HSCs. KG1 cells (A) and bone marrow CD34+ hematopoietic stem cells (BM HSCs) (B), preincubated with buffer (▪), 10-5 M fMLP (▦), or 10-7 M uPAR84-95 (□), were plated in Boyden chambers and allowed to migrate toward 100 ng/mL SDF1. 100% values represent cell migration in the absence of chemoattractants. Values are the mean ± SD of 3 experiments performed in triplicate. Error bars are not shown when graphically too small.