Autonomy of NOD HSCs maps to Idd9 locus. Purified KSL cells were administered to allogeneic recipients and long-term survival was evaluated. (A) Survival of C3H recipients exposed to 950 cGy TBI and given 10 000 KSL cells from NOD (□) or NOR (▵) mice. Conditioned controls receiving no KSL cells are also shown (solid line). (B) Survival curves of C3H recipients given 10 000 KSL cells from NOD mice (□), NOD B10.Idd5 congenic mice (○), or NOD B10.Idd3, 10, and 18 congenic mice (▵). (C) Survival curves of B10.BR recipients given 10 000 KSL cells from NOD mice (□), NOD B10.Idd9.3 congenic mice (⋄), NOD Idd9.1, 9.2, and 9.3 congenic mice (○), or NOD Idd9.2, 9.3 congenic mice (▵). Results shown for each donor type combine the survival data from 2 to 5 separate transplant experiments. Survival of the different transplant recipient groups was compared via Kaplan-Meier survival curves using the SPSS 12.0 for Windows statistical software package. Log-rank comparisons were performed and the P values for each comparison are shown. n.d. indicates not determined; n.a., not applicable.