Figure 2.
hMSCs convert activating APCs into T-cell inhibitors. Either CD4+ T cells (A,C) or CD8+ T cells (B) were stimulated with SEB (1 ng/mL) in the absence (□) or presence (▪) of hMSCs (5 × 104 cells) and increasing numbers of either monocytes (A,B) or DCs (C). T-cell activation was followed by either IFN-γ secretion, incorporation of [3H]thymidine, or IL-5 secretion to the media. Each panel shows 1 representative experiment of 3.