Effects of the S128R E-selectin polymorphism on LPS-induced plasma levels of cytokines and soluble (s) E-selectin. Healthy male volunteers (n = 157) received an intravenous infusion of 2 ng/kg endotoxin (LPS). The polymorphism (▪) slightly enhanced plasma levels of tumor necrosis factor alpha (TNF, top) at 3 hours, and interleukin-6 (IL-6) levels at 6 hours (middle) by 30%, but had no major effect on basal or cytokine-induced plasma levels of soluble (s) E-selectin (bottom). □ indicates Ser128 common genotype. Data are mean plus or minus standard error of the mean (SEM). To enhance the visibility values in the low range, cytokines are plotted on a logarithmic scale.