The S128R E-selectin genotype enhances LPS-induced activation of coagulation. Healthy male volunteers (n = 157) received an intravenous infusion of 2 ng/kg LPS. The polymorphism (▪) enhanced thrombin generation by 50% to 80% as measured by prothrombin fragment F₁₊₂ levels (top), and increased fibrin generation 2-fold as measured by D-dimer levels (middle), but had no significant effect on fibrinolysis as measured by plasmin antiplasmin (PAP) complexes (bottom). □ indicates Ser128 common genotype. Data are mean plus or minus SEM; ^*P < .05, ^**P < .01 between genotypes.