Figure 2.
![Figure 2. RNAi-induced down-regulation of FLT3 sensitizes Ba/F3 FLT3-ITD transfectants and Molm-14 cells to treatment with MLN518. (A) Dose-dependent decrease in cell proliferation following treatment with decreasing concentrations of FLT3 siRNA (Ba/F3 FLT3-ITD cells [n = 8] and Molm-14 cells [n = 5]). (B) Treating Ba/F3 FLT3-ITD cells (n = 8) and Molm-14 cells (n = 5) with FLT3 siRNA increases their sensitivity to treatment with the FLT3 inhibitor MLN518. Error bars indicate standard deviation.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/105/7/10.1182_blood-2004-07-2758/6/zh80070576530002.jpeg?Expires=1735547258&Signature=vY74ex1sUGvKud9WOBaYMTphwc5OPWyhx6zHJpDscOKUJMbMpiV4~gITvlFNhtjM8Jt1FSHKl6wI~HMZQgLR7M~JMRyT0Yc~bwWZTg32y7k-CL06GB54P22pyneUHJFY2b2rkH8DOPWJRHdhzlpCMKWjBT-cgzGBr6ff2aLX7wGh62L-xyVn93WIHiwLjXmbtplHwofDFP5pvshZvm7swDXwLP69LGJnFlfDfkE-lnIQvrxYYRbFXzHlzNQAZxc1G0o640P4yqifrFFAuVN7x8vFcPWk4aBNSNdAIZKomJ5HBygfio0l5PmddkM9EMw3yS2ixPhLrIknXsHSoor4~Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
RNAi-induced down-regulation of FLT3 sensitizes Ba/F3 FLT3-ITD transfectants and Molm-14 cells to treatment with MLN518. (A) Dose-dependent decrease in cell proliferation following treatment with decreasing concentrations of FLT3 siRNA (Ba/F3 FLT3-ITD cells [n = 8] and Molm-14 cells [n = 5]). (B) Treating Ba/F3 FLT3-ITD cells (n = 8) and Molm-14 cells (n = 5) with FLT3 siRNA increases their sensitivity to treatment with the FLT3 inhibitor MLN518. Error bars indicate standard deviation.
