Detection of apoptosis-regulating proteins in biopsy specimens of primary nodal DLBCL. (A) c-Flip demonstrating brown, predominantly cytoplasmic, staining. (B) Bcl-2 demonstrating brown cytoplasmic staining. (C) XIAP demonstrating brown cytoplasmic staining. Arrows indicate apoptotic cells. Note high numbers of cells with apoptotic morphology in clearly Bcl-2- and XIAP-positive patients and the absence of cells with apoptotic morphology in c-Flip-positive patients.