Abnormal lymphatic architecture in skin of kCYC^+/- transgenic mice. Whole-mount staining of nontagged TG (left panels) and WT (right panels) ear skin for CD31 (A,C) and podoplanin (B-C) showing normal blood vessel number and architecture (A,C) and abnormal lymphatic architecture (B-C) in TG mice, that is, lymphatics of TG mice are lacking valvelike structures (arrowheads) (× 200-400).