Figure 4.
Low doses of RAPA inhibit the growth of AML progenitors. Freshly isolated AML cells from 23 patients were adjusted to 1 × 105 cells/mL final concentration, and grown in methylcellulose medium supplemented with 10% 5637-CM and increasing concentrations (ie, 0, 0.1, 1, 10, and 100 nM) of RAPA. CFU-Ls were scored at day 7. Results are presented as percentage of CFU-L for each RAPA-treated AML samples relative to untreated cells. The average curve is shown. Each symbol represents CFU-L's growth of AML samples at the corresponding concentration.
