CD40L/OX40L-stimulated CTLs present increased amounts of proinflammatory T_H1 cytokines and lower amounts of T_H2 cytokines and of IL-10. The figure shows the amount of cytokines secreted at week 3 (mean + SD in picograms per milliliter) by CTLs stimulated by the different B-CLL target cells (nonmanipulated, OX40L-, CD40L-, and CD40L/OX40L-expressing cells). Cell concentration was maintained at approximately 2 × 10⁶/mL for all the conditions and samples tested. (A-F) IL-2, IFN-γ, TNF-α, IL-4, IL-5, and IL-10, respectively. ^*Significant difference (P < .05). For TNF-α and IL-4, P = .06 and P = .07, respectively.