Generation of T cells from BM CD34⁺ cells obtained from SIV-infected macaques. (A) Differentiation of simian CD34⁺ BM after 16 days of coculture with human thymic stromal cells; ○, mean value (± SD) of cells from 6 uninfected cynomolgus macaques; •, mean values (± SD) of cells of 8 macaques infected with the primary SIVmac251 isolate. BM cells were obtained 6 months after infection. (B) Proportion of BM progenitors of various phenotypes after 8 days of coculture with human thymic stromal cells; □, mean ± SD of cells from 6 uninfected cynomolgus macaques; ▪, mean ± SD of cells of 8 cynomolgus macaques infected with SIV-mac251, 6 months after intravenous inoculation. (C) Changes in the T-cell differentiation potential of CD34⁺ BM cells obtained from 3 cynomolgus macaques (mean ± SD) at various time points after the infection of macaques with SIVmac251.