Frizzled 9 KO mice show decreased survival and elevated WBC. (A) Survival plots of WT129 SvEv mice (• n = 14) versus Fzd9 KO (▴ n = 36). (B) Peripheral blood counts in cells/μL for 17 representative Fzd9^-/- mice ranging in age from 6 to 14 months with normal value ranges denoted by rectangles for each cell type. WBC indicates total white blood cell count; Neuts, neutrophils; Monos, monocytes (× 10 for display purposes); Eos, eosinophils (× 10); and RBC, red blood cells (× 10^-3).