Combination treatment of NOD mice with anti-CD8 and anti-CD154 mAb further enhances engraftment and reduces the minimum TBI dose to establish chimerism. Percentage of engraftment (A) and chimerism (B) obtained in NOD BMT mice treated with either anti-CD8 mAb on day -3(•), anti-CD154 mAb on day 0 (□), or the combination of both mAbs (▪). ○ indicates no mAb. n = at least 6 and up to 21 animals per group. Error bars indicate ± SD.