Nonmyeloablatively conditioned NOD recipients with chimerism exhibit decreased insulitis. The pancreata from 12-week-old and 6- to 7-month-old naive NOD mice as well as from chimeric NOD mice conditioned as indicated, were harvested and fixed in 10% buffered formalin. H&E-stained sections of each pancreas were read by a pathologist in a blinded fashion and each were assigned an insulitis score as noted in “Materials and methods.” Results shown are the mean score ± SD of evaluated sections; n.d. indicates no insulitis detected in the evaluated sections. Error bars indicate ± SD.