Expression of CXCL12 in HPV lesions from patient with and without WHIM. CXCL12 immunostaining of control skin samples: healthy skin (A), seborrheic keratosis (B), inflammatory skin (C), and epidermoid carcinoma (D). CXCL12 expression in WHIM wart epidermis (E), WHIM dysplastic condyloma epidermis (F), non-WHIM wart (G), non-WHIM condyloma (H). WHIM wart epidermis (same specimen as in panel E) immunostained with IgG2a isotype-matched control antibody (Ab) (I). CXCL12 expression in non-WHIM (J) and WHIM (K) dermal mononuclear infiltrates. Cells with fibroblast (arrows) or dendritic cell morphology (arrowheads) are shown (J-K). CXCR4 immunostaining of WHIM wart dermis and epidermis (L). The same specimen was similarly processed with IgG1 isotype-matched control Ab (M). Original magnification, × 400 (A-C,G,H), × 200 (D-F,I), × 600 (J-K), × 100 (L-M).