Proposed pathways for rapamycin-induced TF production in endothelial cells. We suggest that (1) TF is up-regulated by the MAP kinase pathway, (2) inadequate TF production is controlled by simultaneous activation of negative regulating pathways, and (3) inhibition of mTOR with rapamycin leads to complete loss of p70S6 kinase-mediated negative regulation. PDK1 indicates 3-phosphoinositide-dependent kinase 1.