PD166326 prolongs the survival of mice with the CML-like disease. (A) Mice reconstituted with P210-transduced BM cells received PD166326 (PD16), imatinib mesylate, or placebo according to the indicated treatment schema bid indicates twice a day. (B) Survival of the indicated treatment cohort (N) is depicted as the number of days after bone marrow (BM) reconstitution (day 0). The start of drug treatment (Rx) is indicated at the arrow. PD166326-(▴) and imatinib mesylate (•)–treated animals were electively killed on day 33 to 37 for analysis. ▪ indicates mice receiving placebo. The results depicted are from 2 independent experiments.