Apoptosis induction by PTL or PTL/PGJ2 correlates to inhibition of NF-κB and increased phosphorylation of p53(ser15). (A) Percent viability and NF-κB electrophoretic mobility shift assay (EMSA) of a representative AML specimen treated with increasing concentrations of PTL alone (•) or in combination with 0.5 μM PGJ2 (▪). The viability is compared with and Ara-C (5μM; ♦) treatments. (B) Immunoblot analysis of phospho-p53(ser15) and actin for the same representative AML specimen treated with increasing dose of PTL 0.5 μM PGJ2.