Localization of wild-type MMSET proteins. (A) Live cell localization of MMSET I, MMSET II, and RE-IIBP tagged with GFP at the N-terminus in transiently transfected HeLa cells. The location of the nucleus and nucleoli is identified by the live cell permeable DNA dye, Hoechst. (B) Live cell localization of MMSET I, MMSET II, and RE-IIBP tagged with GFP at the C-terminus. (C) Colocalization of MMSET II–GFP with DNA/chromatin. The fluorescence profile is generated from the area covered by the red arrow. The blue plot represents the intensity of the Hoechst stain; the green plot, the intensity of MMSET II–GFP.