Structure and amino acid sequences of Runx family molecules. (A) Schematic representation of the structure of Runx molecules. runt indicates the Runt domain; NLS, nuclear localizing signal; NMTS, nuclear matrix targeting signal; TA, trans-activation domain; ID, auto-inhibitory domain; VWRPY, VWRPY-motif; Q, glutamine (Q)-residue stretch; A, alanine (A)-residue stretch. Numerals within parentheses below the AML2 and AML3 schemes indicate the percentages of amino acid (AA) identity of the subdomains in comparison with those of AML1. (B) Comparison of amino acid sequences of the Runx molecules represented by the 1-letter code. Manual alignment was performed visually. Runt domain sequences are highlighted in pink. Dashes (–) indicate gaps. Numerals to the right of the columns represent the positions of the amino acid residues.