Reduced intestinal MCp reservoir in wild-type mice by treatment with anti-α4β7 integrin and anti-CXCR2 antibodies. (A-B) Bars represent the intestinal MCp concentrations (A) and the absolute number of intestinal MCps (B) in mice treated with saline or antibody directed against the indicated integrins. Values are the mean ± SEM for 4 experiments. ^*Statistical significance (P < .05) relative to mice treated with anti-β1 integrin antibody. (C-D) Bars represent the intestinal MCp concentrations (C) and the absolute number of intestinal MCps (D) in mice treated with normal rabbit IgG or antibody directed against the chemokine receptor CXCR2. Values are the mean ± SEM for 3 experiments. ^*Statistical significance (P < .05) relative to mice treated with normal rabbit IgG.