Immunohistochemical staining with anti-HGAL monoclonal antibody in lymphomas. (A-C) Follicular lymphoma stained with the CD10, BCL2, and anti-HGAL monoclonal antibody highlights neoplastic follicles and interfollicular B cells. (D) Hematoxylin and eosin-stained section of Burkitt lymphoma shows uniform cells admixed with starry sky histiocytes. (E) Burkitt lymphoma cells show staining for HGAL protein. (F) TMA cores of DLBCL show a range of staining from none to weak/partial staining to intense staining of all neoplastic cells. (G) High magnification of a core of a DLBCL shows moderate to strong staining within the cytoplasm. (H-I) Extranodal marginal zone B-cell lymphoma of the lymph node and gastrointestinal tract lacks staining for HGAL although the stain highlights entrapped GCs within the neoplastic infiltrate. (J) Hematoxylin and eosin–stained section of plasma cell myeloma shows sheets of atypical plasma cells with prominent nucleoli. (K) Plasma cell myeloma shows staining for HGAL protein. Original magnifications: A-C, H, and I, ×150; F, ×30; G, ×300; D, E, J, and K, ×600.